2012•Journal of psychiatryRequires access

A comparative study of ziprasidone vs. risperidone in treatment of schizophrenia dominated by negative symptoms

Zhenghua Lin

Abstract

Objective To compare the efficacy and side effects of ziprasidone and risperidone in the treatment of schizophrenia dominated by negative symptoms.Methods 80 schzophrenic inpatients dominated by negative symptoms were randomized into ziprasidone group(40 cases) and risperidone group(40 cases) treated for 8 weeks.The efficacy and side effects were evaluated with Positive and Negative Symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS).Results There was no significant difference in efficacy between the two groups(P0.05).However,the incidence rate of side effects in risperidone group was significantly higher than that in ziprasidone group(P0.05).Conclusion Ziprasidone is effective and safe for the treatment of schizophrenia dominated by negative symptoms.

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Key concepts: Ziprasidone, Risperidone, Negative symptom, Schizophrenia (object-oriented programming), Internal medicine, Positive and Negative Syndrome Scale, Side effect (computer science), Psychology