2007•International Journal of Pathology and Clinical MedicineRequires access
Research advance of multidrug resistance gene
Zeshi Cui
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Abstract
Multidrug resistance(MDR),which is defined as cross resistance of tumor cells to many chemotherapy drugs,is the main cause for failure in tumors chemotherapy.Using multidrug resistant tumor cell lines and animal models,many studies revealed numbers of mechanisms involved in multidrug resistance.A series of reversal drugs with different mechanisms have been discovered.