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2006•Bulletin of Chinese CancerRequires access

Research Progress of Multidrug Resistance to Cancer Chemotherapy

Derui Li

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Abstract

Multidrug resistance (MDR) of cancer cells is a major cause of failure in chemotherapy. The mechanism of multidrug resistance is vary, while much attention was paid on the expression of ABC(ATP binding cassette) transporter. This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.

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What this paper is about

Multidrug resistance (MDR) of cancer cells is a major cause of failure in chemotherapy. The mechanism of multidrug resistance is vary, while much attention was paid on the expression of ABC(ATP binding cassette) transporter. This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.

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Available abstract

Multidrug resistance (MDR) of cancer cells is a major cause of failure in chemotherapy. The mechanism of multidrug resistance is vary, while much attention was paid on the expression of ABC(ATP binding cassette) transporter. This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.

Key concepts: Multiple drug resistance, Cancer chemotherapy, ATP-binding cassette transporter, Chemotherapy, Cancer, Drug resistance, Medicine, Transporter

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