Detection of Serum LPO,GSH-PX and SOD in Patients with Acute Cerebrovascular Disease and Its Significance

Objective To investigate the role of serum lipid peroxide(LPO),glutathione peroxidase(GSH-PX) and superoxide dismutase(SOD).Methods The levels of serum LPO,GSH-PX and SOD in 44 patients with acute cerebrovascular disease were determined by biochemistry methods.Results The level of serum LPO rose signifi-cantly in 6 hours after the onset of cerebrovascular diseases in contrast with the decrease of serum GSH-PX and SOD.In 6 to 24 hours the changes of these values were more obvious.In 24 to 72 hours serum SOD and LPO decreased,but serum GSH-PX increased appreciably.All these changes were significant compared with the control groups(P0.01,P0.05).In the first three days after the onset of cerebral infarction,serum SOD,GSH-PX were lower and serum LPO was higher than in the patients of cerebral hemorrhage.Conclusion It recommends that using free radical scavenger to treat the cerebrovascular diseases is more effective in 6 hours after the onset.