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2010•Zhongguo quanke yixueRequires access

Free Radical Injury in Development of Acute Cerebral Infarction Combined with Metabolic Syndrome

Jiamin Li

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Abstract

Objective To study the role of free radical injury in the development of acute cerebral infarction(CI) combined with metabolic syndrome(MS).Methods A total of 72 CI patients with MS(group A),110 without(group B) and 150 controls(group C) were enrolled in this study.All patients were scored according to China Stroke Scales(CSS).Venous blood was collected to determine the levels of serum ferritin,lipid peroxide(LPO) and the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px).Results There was significant difference in CSS between groups A(17±2) and B(13±3)(t=2.73,P0.05).The levels of serum ferritin,LPO were significantly higher in group A than in groups B,C,but the activities of SOD,GSH-Px lower(P0.05).Conclusion Free radical injury may be one of the important pathogenses of acute CI complicated by MS.

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Objective To study the role of free radical injury in the development of acute cerebral infarction(CI) combined with metabolic syndrome(MS).Methods A total of 72 CI patients with MS(group A),110 without(group B) and 150 controls(group C) were enrolled in this study.All patients were scored according to China Stroke Scales(CSS).Venous blood was collected to determine the levels of serum ferritin,lipid peroxide(LPO) and the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px).Results There was significant difference in CSS between groups A(17±2) and B(13±3)(t=2.73,P0.05).The levels of serum ferritin,LPO were significantly higher in group A than in groups B,C,but the activities of SOD,GSH-Px lower(P0.05).Conclusion Free radical injury may be one of the important pathogenses of acute CI complicated by MS.

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Available abstract

Objective To study the role of free radical injury in the development of acute cerebral infarction(CI) combined with metabolic syndrome(MS).Methods A total of 72 CI patients with MS(group A),110 without(group B) and 150 controls(group C) were enrolled in this study.All patients were scored according to China Stroke Scales(CSS).Venous blood was collected to determine the levels of serum ferritin,lipid peroxide(LPO) and the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px).Results There was significant difference in CSS between groups A(17±2) and B(13±3)(t=2.73,P0.05).The levels of serum ferritin,LPO were significantly higher in group A than in groups B,C,but the activities of SOD,GSH-Px lower(P0.05).Conclusion Free radical injury may be one of the important pathogenses of acute CI complicated by MS.

Key concepts: Medicine, Lipid peroxide, Glutathione peroxidase, Superoxide dismutase, Internal medicine, Ferritin, Venous blood, Cerebral infarction

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