2008•China Medical HeraldRequires access
The relation between connective tissue growth factor and ventricular hypertrophy in the rats with renovascular hypertension
MA Ye-xin
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Abstract
Objective:To study the relation between connective tissue growth factor and ventricular hypertrophy in the rats with renovascular hypertension. Methods: Some two-kidney one-clip (2K1C) renovascular hypertension(RVH)rats were established. Then they were randomly divided into two groups:RC1 and RC2. In addition,sham-operated rats were designed as controls(SC). The left ventricular weight(LVW) and the ratio of left ventricle weight to body weight(LVW/BW) were measured when the rats were killed at the endpoint of the study. The CTGF protein in the left ventricular myocardium were assayed by immunohisto- chemical methods. Results: ①Significant ventricular hypertrophy appeared at the 8th week and became more serious at the 12th week after surgery.②The expression of CTGF protein in the left ventricular myocardium increased significantly in RC1 rats and RC2 rats(compared with the sham rats),and the expression of CTGF protein in RC2 rats increased more significantly than in RC1 rats. Conclusion:Increased expression of CTGF protein in left ventricular myocardium of rats with renovascular hypertension indicate that CTGF may play important roles in the development of ventricular hypertrophy of RVH rats.