Prospective study on the value of plasma level of adiponectin in predicting gestational diabetes mellitus

Objective:To investigate the value of plasma level of adiponectin in predicting gestational diabetes mellitus(GDM),then to provide scientific evidence for early prediction of GDM.Methods:Pregnant women with high risk factors of GDM were enrolled into this study,body height,body weight,blood pressure,plasma adiponectin,fasting blood glucose and insulin,total cholesterol,triglyceride were tested at 14～18 weeks of pregnancy.And plasma adiponectin,oral glucose tolerance test(OGTT),blood insulin were tested again at 24～28 weeks of pregnancy,then the insulin resistance index was calculated.According to the result of OGTT,two groups were divided,including GDM group and normal glucose tolerance(NGT) group to summary the incidence of GDM and compare all the test indexes at early and midtrimester pregnancy.Results:The plasma level of adiponectin in GDM group was significantly lower than that in NGT group at 14～18 weeks and 24～28 weeks of pregnancy(P0.001).Plasma adiponectin correlated negatively with body weight index(BWI) before pregnancy,fasting blood glucose and insulin,insulin resistance index(IRI) and body weight of neonates.Conclusion:Plasma level of adiponectin is a sensitive index in predicting GDM,it descends significantly at 14～18 weeks of gestation,being before clinical diagnosis of GDM,so it can be used to predict GDM.