Influence of Huazhuo Jiedu Recipe on Rats with Reflux Esophagitis Combined with Turbidity Toxin in Chiese Medicial Syndrome

Objective: To explore the mechanisms of Huazhuo Jiedu recipe in treating reflux esophagitis( RE). Method: Sixty male Wistar rats were randomly divided into control group,model group,omeprazole group,Huazhuo Jiedu recipe group of fifteen rats each group. The RE model was established using partial pyloric ligation and cardiomyotomy except the rats in control group. The rats in control and model groups were intragastrically administrated with distilled water. The rats in omeprazole group were intragastrically administrated with 3. 6 mg·kg-1omeprazole. The rats in Huazhuo Jiedu recipe group were intragastrically administrated with12. 5 g·kg-1Huazhuo Jiedu recipe. The histopathology in esophagus tissues was observed after 8 weeks treatment.Meanwhile,the content of gastrin( GAS),motilin( MTL) and vasoactive intestinal peptide( VIP) in serum were tested by ELISA. Result: Omeprazole and Huazhuo Jiedu recipe could improve the pathological changes of esophageal mucosa,there were statistically significant difference as compared with model group( P 0. 05).Huazhuo Jiedu recipe could increase contents the GAS,MTL,decrease the content of VIP,there were significant difference as compared with model group( P 0. 05). Conclusion: Huazhuo Jiedu recipe has effect on RE rats,which may be chieved by increasing the contents of GAS and MTL,reducing the content of VIP in serum.