Diagnostic Significance of Serum Total Bile Acid in Hepatobiliary Diseases

Objective To explore diagnostic significance of serum total bile acid (TBA) in patients with hepatobiliary diseases. Methods The level of serum TBA was detected by cycle enzyme method in 211 patients with hepatobiliary diseases,including cirrhosis,obstructive jaundice,and primary liver cancer,and 38 control subjects. Other liver function parameters were also determined. Results The level of TBA in patients with hepatobiliary diseases was significantly higher that in control subjects (P 0.01),and in patients with cirrhosis and obstructive jaundice it was significantly higher than in patients with primary liver cancer (P 0.01). In patients with hepatobiliary diseases,the positive rate of TBA was higher than other liver function parameters. The level of serum TBA was significantly correlated with total bilirubin and direct bilirubin (P 0.01). Conclusion TBA is a sensitive biochemical index to reflect hepatobiliary diseases and closely correlated with bile metabolism. TBA plays an important role in the diagnosis of hepatobiliary diseases.