Clinical value analysis on serum TBA and ALT combined determination for hepatobiliary patients

Objective To establish the combined determination mode for serum total bile acid(TBA) and alanine aminotransferase(ALT) and to discuss its clinical value for the hepatobiliary patients.Methods The Hitachi 7600-020 fully automatic biochemical analyzer was adopted to conduct the combined detection of serum TBA and ALT in 223 cases of hepatobiliary diseases and 60 healthy individuals.Results Serum TBA in various hepatobiliary diseases was significantly increased compared with the control group.The TBA positive detection rate in acute hepatitis,chronic hepatitis,liver cancer and liver cirrhosis were 100.0%,89.1%,88.4%,84.0% and 75.9% respectively.The ALT positive detection rate in acute hepatitis,chronic hepatitis,gall disease,liver cancer,liver cirrhosis were 100.0%,81.8%,73.9%,36.0% and 37.9% respectively.ALT was increased to different degrees in varying gall diseases(P0.01).Serum TBA in acute hepatitis,chronic hepatitis and gall disease was significantly increased(P0.01),with the positive detection rate of more than 80%.The positive detection rate of TBA and ALT reached to 100.0% in acute hepatitis,but which in liver cancer and liver cirrhosis had statistical difference(P0.05) and which in gall diseases also had greater difference(P0.05).Conclusion TBA and ALT are the important and sensitive indicators for hepatobiliary diseases,but their specificity and sensitivity are not consistent in different hepatobiliary disease processes with different advantages and disadvantages.Therefore,the TBA and ALT combined determination has realistic clinical value for monitering various hepatobiliary diseases.