Effect of intra-arterial thrombolysis with urokinase on acute cerebral infarction

Objective: To investigate the clinical efficacy and safety of intra-arterial thrombolysis with urokinase for acute ischemic cerebral infarction.(AICI).Methods: 31 patients of AICI in 3-24 h(carotid artery occlusion in 6 h,the vertebrobasilar occlusion within 24 h) were treated by intra-arterial thrombolysis with urokinase.Recanalization rate,neurologic impairment score were observed and compared.Results: The recanalization rate of observation group was 87.1%.After treatment,the There was significant difference in neurologic impairment score between two groups(P0.01).Total effective rate in observation group(90.32%) was significantly higher than that in control group(61.29%)(P0.01).Conclusion: Intra-arterial thrombolysis with urokinase has significant effect and high recanalization rate.This treatment provide an early neurological deficit recovery and can improve prognosis.So it′s an effective treatment of cerebral infarction.