Spectrophotometric determination of clarithromycin capsules dissolution by charge-transfer comples with alizarin red

Objective To establish a method for the determination of clarithromycin capsules dissolution based on charge-transfer reaction with alizarin red.Methods The dissolution test was conducted according to Pharmacopoeia of People′s Republic of China,using phosphate buffer solution as medium,with a stirring speed of 100 r/min.The solution was withdrawn after 45 min.The absorbance of dissolution solutions was measured at 525 nm.Dissolution limit is 75% of the labeled amount.Results Good linear correlation was achieved at the range of 60.4~151.0 μg/ml,(r=0.999 8).The mean recovery was 100.6%,RSD was 0.8%.Conclusions The method is accurate,simple,and suitable to the determination of clarithromycin capsules dissolution.