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2010•Chinese Journal of Spectroscopy LaboratoryRequires access

Determination of Dissolution of Fosfomycin Sodium by Spectrophotometry with Alizarin

Yi Liu

Open publisher page 2 citations

Abstract

A new spectrophotometric method was developed for the determination of fosfomycin sodium based on formation of 1:1 charge transfer complex with alizarin in ethanol solution.The complex maximum absorption is at 545nm The apparent molar absorptivity is 3.47×103L·mol-1·cm-1.The calibration curves are linear in the concentration range of 1.4—60mg·L-1.This proposed method has been applied to determination of fosfomycin sodium with satisfactory results.The recovery is 99.6%—100.5%.

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What this paper is about

A new spectrophotometric method was developed for the determination of fosfomycin sodium based on formation of 1:1 charge transfer complex with alizarin in ethanol solution.The complex maximum absorption is at 545nm The apparent molar absorptivity is 3.47×103L·mol-1·cm-1.The calibration curves are linear in the concentration range of 1.4—60mg·L-1.This proposed method has been applied to determination of fosfomycin sodium with satisfactory results.The recovery is 99.6%—100.5%.

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Available abstract

A new spectrophotometric method was developed for the determination of fosfomycin sodium based on formation of 1:1 charge transfer complex with alizarin in ethanol solution.The complex maximum absorption is at 545nm The apparent molar absorptivity is 3.47×103L·mol-1·cm-1.The calibration curves are linear in the concentration range of 1.4—60mg·L-1.This proposed method has been applied to determination of fosfomycin sodium with satisfactory results.The recovery is 99.6%—100.5%.

Key concepts: Molar absorptivity, ALIZARIN RED, Fosfomycin, Spectrophotometry, Chemistry, Alizarin, Sodium, Calibration curve

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