Coagulation,anticoagulation and fibrinolytic function changes in patients with progressive cerebral infarction

Objective To early diagnose progressive cerebral infarction and have more time in thrombolytic treatment,and to discuss.the unique clinical classification and laboratory test of progressive cerebral infarction.Methods The exploratory research was done in 209 cases with progressive cerebral infarction.Prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fib),von Willebrand factor(vWF),platelet aggregation test(PAgT),anti-thrombin activity(AT),tissue-type plasminogen activator (t-PA) and its inhibitor(PAI-1) in the patients were assayed.Results PT,APTT,TT,AT-A and(t-PA) in the patients with progressive cerebral infarction were significant shorter or less than that in patients with complete cerebral infarction. But the concentration of Fib,vWF,PAgT and PAI-1 in the patients were significant higher than that in patients with complete cerebral infarction.Conclusion The function of anticoagulation and fibrinolysis in the patients with progressive cerebral infarction are significantly lower than that in patients with complete cerebral infarction.