The Clinical Study of Coagulant, Anticoagulant and Fibrinolytic Function in Patients of Acute Cerebral Infarction.

Objective: We assayed coagulant, anticoagulant and f ibrinolytic function of patients with acute cerebral infarcion to provide scie ntific basis for early diagnosis and therapy of this disease. Methods:1 396 pati ents with acute cerebral infarction were divided into two groups:completed cereb ral infarction group and advanced cerebral infarction group. All patients were p rospectively reviewed by examining the level of their blood prothrombin time(PT) ,actived partial thromboplastin time(APTT),thrombin time(TT),Fbg,vWF and the act ivity of antitrombin (AT),AT antigen and tissue type plasminosen activator(t-PA ).Results:The level of PT, TT, APTT and vWF in completed cerebral infarction gro upare significantly lower than advanced cerebral infarction group(P 0.001).The level of Fbg in completed cerebral infarction group are lower th an advanced cerebral infarction group (P0.05).PAgT in complete d cerebral infarction group is also lower. However, the activity of AT,AT antige n and t PA in completed cerebral infarction group are significantly higher than advanced cerebral infarction group (P0.001). Conclusion: The level of PT, TT, APTT, vWF, AT ,AT antigen and t-PA∶A can be adopted to as say the clinical therapy effect and prognosis of acute cerebral infarction.