Influence and therapeutic analysis of edaravone on the serum levels of SOD in patients with acute cerebral infarction

Objective To explore the influence of edaravone on the serum levels of SOD in patients with acute cerebral infarction and therapeutic efficacy.Methods Sixty-two cases with acute cerebral infarction were divided randomly into control group and treatment group.Two groups were given routine treatment.The treatment group was added edaravone for 14 days.The serum levels of SOD were measured before treatment and 7,14 and 21 d after treatment.Therapeutic efficacy was evaluated by The European Stroke Scale(ESS).Results The serum level of SOD in the treatment group and the control group had no significant difference before treatment(P0.05).The serum level of SOD in two group was significantly higher after treatment(P0.05).After treatment the serum levels of SOD in the treatment group was much higher than that in control group(P0.01).ESS of the treatment group and control group at 7 d,14 d and 21 d had significant differences.Conclusion To investigate the changes of lipid peroxidation and the therapy effect of a free radical scavenger on acute cerebral infarction by monitoring the levels of SOD in patients,all this will play an active role in treatment of disease through adjusting and formulation the treatment protocols.