Study on transdermal permeation of paeonol liposomes in vitro

Objective To prepare the paeonol liposomes and investigate its penetration characteristics as a transdermal vehicle.Methods The liposomes were prepared by a film-ultrasonic technique.We conducted the examination of in vitro transdermal permeation on rat's skin with diffusion device to evaluated the transdermal permeation ability and the drug amount left in the skin.Results The liposomes prepared were mono-layer vehicles with an average entrapment rate of 72.8% and the particle size of 163.8 nm.Compared with the solution of 30% ethanol,the liposomes had lower transdermal speed but higher drug content in the skin.Conclusions The preparation method of paeonol liposomes was proved to be applicable.The paeonol liposomes can make the drug accumulate in skin,which was expected to release steadily and continuously.