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2010•Huaxi yaoxue zazhiRequires access

Study on transdermal drug delivery system of paeonol

Pan Wang

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Abstract

OBJECTIVE To prepare paeonol-loaded transfersomes and charecterize the transdermal effects in vitro.METHODS Paeonol transfersomes were prepared by thin-film ultrasonic method.The different dosage regimes on the trandermal resorption of paeonol were evaluated through excised mice skin in vitro using modified Franz-diffustion cells.RESULTS The average particle size of the paeonol transfersome optimized formula was evenly distributed.The cumulative penetration rate in 8 h of transfersome with cholesterol were 81.22%.Conventional liposome was 49.66%.Paeonol water-alcohol suspension was 42.22%.CONCLUSION The preparation method of paeonol transfersome was simple and suitable.The particle size are relatively small and homogeneous,and can improve significantly the transdermal delivery speed of paeonol.

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OBJECTIVE To prepare paeonol-loaded transfersomes and charecterize the transdermal effects in vitro.METHODS Paeonol transfersomes were prepared by thin-film ultrasonic method.The different dosage regimes on the trandermal resorption of paeonol were evaluated through excised mice skin in vitro using modified Franz-diffustion cells.RESULTS The average particle size of the paeonol transfersome optimized formula was evenly distributed.The cumulative penetration rate in 8 h of transfersome with cholesterol were 81.22%.Conventional liposome was 49.66%.Paeonol water-alcohol suspension was 42.22%.CONCLUSION The preparation method of paeonol transfersome was simple and suitable.The particle size are relatively small and homogeneous,and can improve significantly the transdermal delivery speed of paeonol.

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Available abstract

OBJECTIVE To prepare paeonol-loaded transfersomes and charecterize the transdermal effects in vitro.METHODS Paeonol transfersomes were prepared by thin-film ultrasonic method.The different dosage regimes on the trandermal resorption of paeonol were evaluated through excised mice skin in vitro using modified Franz-diffustion cells.RESULTS The average particle size of the paeonol transfersome optimized formula was evenly distributed.The cumulative penetration rate in 8 h of transfersome with cholesterol were 81.22%.Conventional liposome was 49.66%.Paeonol water-alcohol suspension was 42.22%.CONCLUSION The preparation method of paeonol transfersome was simple and suitable.The particle size are relatively small and homogeneous,and can improve significantly the transdermal delivery speed of paeonol.

Key concepts: Paeonol, Transdermal, Chemistry, Particle size, Liposome, Resorption, Chromatography, Pharmacology

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Study on transdermal drug delivery system of paeonol — Research Paper | ScholarLens