Clinical study of systemic inflammatory response syndrome and multiple organ dysfunction syndrome in acute pancreatitis

Objective To analyze the relationship between systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) in acute pancreatitis, and to explore the therapeutic strategies during progression from SIRS to MODS. Methods 83 acute pancreatitis patients (simple 53, severe 30) were divided into non SIRS and SIRS groups. The SIRS group was again categorized into non infectious SIRS, sepsis and septic shock. The frequency and mortality rates of SIRS, the rates of morbidity and mortality of MODS were all analyzed. All data were processed statistically (chi square test).Results The morbidity of MODS in SIRS group was higher than that non in SIRS group ( P 0.005). The mortality and the morbidity rates of MODS corresponded to the degree of SIRS. The morbidity of SIRS and MODS of severe patients was also higher than those of the simple ones ( P0.05,P 0.01 ). Conclusion The degree of SIRS and infection were closely related to the presence of MODS and prognosis of patients with acute pancreatitis. The prognosis of severe pancreatitis may be partly due to the higher morbidity rates of SIRS and MODS.(Shanghai Med J, 1999,22∶714 716)