A Randomized Controlled Clinical Study on Meropenem in Respiratory Bacterial Infections

Objective To evaluate the efficacy and safety of meropenem in the treatment of respiratory bacterial infections.Methods A single blind randomized,parallel controlled clinical trial was carried out.In the study,118 patients were enrolled in treatment group(meropenem 500 mg IV.q8 h),and another 114 patients were enrolled in control group(cefdizime 2 g IV.q12 h),with a course of 7 to 14 d for both groups.The clinical efficacy and safety together with adverse reactions were investigated and compared between 2 groups.Results The cure rates and total effective rates for the treatment and control groups were 83.9%,79.8%,95.8%,and 95.6%,respectively.The bacterial clearance rates were both 99.2%,and the incidences of drug adverse reactions were 7.4% and 6.8%,respectively.There were no statistically significant differences between the results of both groups(P 0.05).Conclusion Meropenem is effective and safe for treating acute bacterial infection.