Comparison of Efficacy between Gatifloxacin and Levofloxacin for Treating Acute Bacterial Infection

Objective To evaluate the efficacy and safety of gatifloxacin in the treatment of acute bacterial infection. Methods A multi-center,single-blind,randomized controlled trial was conducted among 205 patients with bacterial infections. The treatment group were treated with gatifloxacin injection 200 mg iv,gtt,bid and the control group were given with levofloxacin 200 mg,iv,gtt,bid. The duration of treatment in both groups was 7-10 d. Results The recovery rate and effective rate were 68.63% and 93.14% in the treatment group,and 65.05% and 91.26% in the control group respectively (P0.05). The bacteria clearance rate in the two groups were 92.86% and 91.86%,and the adverse reaction rate were 5.88% and 6.80%,respectively (P0.05). Conclusion Gatifloxacin and levofloxacin have the similar efficacy and safety in the treatment of susceptible pathogen infection.