2007•Journal of Modern Food and PharmaceuticalsRequires access
Effect of Antioxidant on the Stability of Omeprazole Sodium for Injection
Yao Xiao-xiao
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Abstract
Objective To study the effect of antioxidant on the stability of Omeprazole sodium for injection's solution.Methods The Omeprazole sodium was used to carry out the alkalinity experiment.According to the impact of different pH value on the stability of the solution in the process of preparation by screening,the solution's outward appearance and the change of its pH value were inspected after the antioxidant was mixed with the Omeprazole sodium.Results After added the antioxidant,the outward appearance and pH value of Omeprazole Sodium are accordant with request,and its stability was improved.Conclusion The value of pH is the major factor that can affect the stability of Omeprazole sodium for injection,and to add an antioxidant under certainpH value condition can further improve its stability.