2007•Chinese Journal of PharmaceuticsRequires access

Study on degradation kinetics of omeprazole sodium in alkaline solutions

Yan Song

Abstract

Objective To study degradation kinetics of omeprazole sodium in alkaline solutions. Methods The experiments were carried out by the means of classical constant temperature. The content of omeprazole sodium was determined by HPLC. Results Hydrolysis reaction of omeprazole sodium in alkaline solutions followed first-order kinetics. Activation energy of the hydrolysis reaction at pH 8.0, pH9.0, pH 10.0, pH 11.0( I= 0.2) was 76.77, 88.66, 93.93, 97.81 kJ·mol-1, respectively. Conclution Stability of omeprazole sodium solution can increase as the pH increase, and it is relatively stable when the pH is more than 10.0.

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Key concepts: Chemistry, Kinetics, Omeprazole, Sodium, Hydrolysis, Degradation (telecommunications), Alkaline hydrolysis, Reaction rate constant