2006•Zhongguo xin yao zazhiRequires access
Optimization of prescription for Rifamycin Sodium for injection and investigation of stability
Xue Mei-yan
Open publisher page 0 citations
Abstract
Objective:To choose the optimal prescription of Bifamyein Sodium for injection and to observe stability.Methods;According to the factors that affect the formation and stability of the preparation,the support reagent and antioxidant were observed separately,and optimized the prescription.The stability was observed by accelerated experiment.Results:The optimum prescrip- tion were Bifamycin Sodium 25 g,Mannitol 3 g,Sodium Metabisufite 1 g,Purified Water to make 500 mL.Conclusion:The antioxidant ability of Sodium Metabisufite was the main factor of long sta- bility of the preparation.