Susceptibility of 78 Candida strains to 4 antifungal agents tested by E test

Objective This study was designed to determine MICs of 4 antifungal agents against Candida isolates and evaluate drug resistance in Candida spp.Methods MICs of amphotericin B (AP), ketoconazole (KE), fluconazole (FL), itraconazole (IT) were determined on 78 clinical isolates of Candida by E test.Results The susceptibility rate of 78 strains of Candida to AP, KE, FL, IT was 89.7%, 92.3%, 85.9% and 85.9% respectively. The susceptibility rate of Candida albicans to the above 4 antifungal agents was 96.9%, 96.9%, 100% and 87.5% accordingly.Conclusions The 4 antifungal agents tested have good antifungal activity against Candida albicans in vitro. Their antifungal activity against other Candida spp. is not as good as against Candida albicans.