Clinical research on chromosomal numerical abnormality in embryos of spontaneous abortion

Objective:To explore the relationship between chromosomal numerical abnormality and spontaneous abortion,analyze the influencing factors of spontaneous abortion. Methods:Fluorescent in situ hybridization technique was used to detect the chromosomal number in chorionic villus of one hundred cases with early spontaneous abortion,then the relationship between chromosomal number and spontaneous abortion was analyzed. Results:Among 100 cases,42 cases were found with chromosomal numerical abnormality,accounting for 42.00%;16 cases were found with chimera,accounting for 16.00%.The most common chromosomal abnormality was triploid,accounting for 35.71%,followed by 45,X and trisomy 16,accounting for 16.67% and 14.29%,respectively.The detection rate of chromosomal abnormality in advanced age group(≥35 years) was 45.46%(10/22),while the detection rate of chromosomal abnormality in non-advanced age group(35 years) was 41.03%(32/78),there was no significant difference(P0.05).The detection rate of chromosomal abnormality in the cases with history of spontaneous abortion was 42.55%(20/47),while the detection rate of chromosomal abnormality in the cases without history of spontaneous abortion was 41.51%(22/53),there was no significant difference(P0.05).The detection rate of chromosomal abnormality in the cases of ≤10 gestational weeks was 45.00%(27/60),while the detection rate of chromosomal abnormality in the cases of10 gestational weeks was 37.50%(15/40),there was no significant difference(P0.05). Conclusion:Chromosomal abnormality is the main cause of early spontaneous abortion,regardless of maternal age,previous history of spontaneous abortion or not,and gestational weeks,the cases with spontaneous abortion at this time may be associated with chromosomal abnormality.Clinicians should pay more attention to chromosomal examination,in order to provide genetic counseling for subsequent pregnancy.