Application of antibiotics during perioperative period of clean surgery

OBJECTIVE To explore the rationality of prophylactic use of antimicrobial agents during the perioperative period of clean surgery.METHODS A retrospective survey on the medical records of 564 patients who underwent clean surgery and discharged from Jan to May 2011 was conducted,the status of application of antibiotics during the period was reviewed by the prepared questionnaire and analyzed statistically.RESULTS There were 431 patients(451 case-times) who used antibiotics with the utilization rate of 76.4%,the mean medication duration was 3.5 d;32 patients stopped using less than 24 h after the surgery,accounting for 7.4%;351 patients were with dosing 30 min-2 h before the skin incision surgery,accounting for 81.4%;196 case-time of patients used penicillin,accounting for 43.4%,the first and second generation of cephalosporins by 147 case-times(32.6%),the third generation of cephalosporins by 21 case-times(4.2%);421 patients use single-drug,accounting for 97.6%.CONCLUSION There remains irrational phenomena in indications of using antibiotics,drug selection,and medication course,which indicates that the use of antibiotics during the perioperative period of clean surgery needs to be further standardized.