Antibiotic prophylaxis during perioperative period of surgery

OBJECTIVE To understand the current status of antibiotic prophylaxis during the perioperative period of surgery and analyze its rationality so as to provide basis for clinical reasonable use of antibiotics.METHODS A total of 419 patient who discharged from the hospital in Aug 2010 were randomly selected,the statistics were taken for statistical analysis.RESULTS All the 419 patients used antibiotics with the utilization rate of 100.0%,cephalosporins were the most frequently used.There were 79(18.85%) patients who used antibiotics more than 2 hours before the surgery,151(36.04%) patients who used antibiotics less than 2 hours before the surgery,189(45.11%) patients who used after the surgery and did not use before the surgery.There were 8(1.91%) patients who used antibiotics continuously for less than 24 hours after the surgery,75(17.90%) patients who used antibiotics between 25-72 hours,and 336(80.19%) patients who used antibiotics for more than 72 hours.The patients who used two-therapy accounted for 24.82%,and the patients who used multiple drugs accounted for 15.04%.CONCLUSION There are some errors in the antibiotics prophylaxis during the perioperative period,including the high starting point of drug selection,inappropriate medication timing,and unclear indications for combination use.It is necessary to strengthen the standard use of antibiotics so as to reduce the incidence of bacterial drug resistance.