Clinical observations on protective actions of Shenmai injection on heart and liver during chemotherapy for malignant tumor of hemopoietic system

Objective:To clinically observe the protective actions of Shenmai injection on heart and liver during chemotherapy for malignant tumor of hemopoietic system.Methods:25 patients with malignant tumor of hemopoietic system complicating cardiovescular disease were randomly divided into three groups.In Shenmai injection group ( n =10) the Shenmai injection 4060 ml infused intravenously once a day at 3 hours before chemotherapy was administered for 10 days.Otherwise the control group ( n =10) was established.In self control group ( n =5) during the first chemotherapy Shenmai injection did not be used but during the second chemotherapy Shenmai injection was added.Results:In the cardiac functions there were not significant differences in three groups before and after therapy.Regarding the Holter examination the numbers of atrial premature systole after therapy in Shenmai injection group were decreased,but in control group they were increased,so that there was significant difference ( P 0 05).In depression of ST segment and change in T wave in comparison between Shenmai injection group and control group as well as semicontrol group there were significant diffenences (all P 0 01).The effective rate for electrocardiogram examination in Shenmai injection group was 90%,in control group 10%,and in semicontrol group 80%.The difference in comparison between Shenmai injection group and cotrol group was significant ( P 0 01).Conclusions:Shenmai injection is able to attenuate the toxic action of chemitherapeutic drugs on heart.