PDGF-D and VEGF in Cervical Squamous Carcinoma of the Expression and its Significance

Objective: Detection of cervical squamous cell carcinoma tissue in platelet-derived growth factor D(PDGF-D) and vascular endothelial growth factor(VEGF) expression, probe into the two in cervical carcinogenesis in the role and significance, in order to investigate the pathogenesis of cervical squamous cell carcinoma and squamous cell carcinoma of the cervix and provide theoretical basis for early treatment. Methods: Detection of cervical squamous cell carcinoma tissue in platelet-derived growth factor D(PDGF-D) and vascular endothelial growth factor(VEGF) expressionpro, be into the two in cervical carcinogenesis in the role and significance, in order to investigate the pathogenesis of cervical squamous cell carcinoma and squamous cell carcinoma of the cervix and provide theoretical basis for early treatment. Results: Cervical squamous cell carcinoma and the expression of VEGF protein in PDGF-D was significantly higher than that in normal cervical tissue(P0.05); PDGF-D and VEGF expression in cervical squamous cell carcinoma and differentiation and lymph node metastasis(P0.05); with age and independent of clinical stage(P 0.05). Spearman correlation analysis found that PDGF-D and VEGF expression was a positive correlation between degree(r=0.346, P0.05). Conclusion: 1. PDGF-D and VEGF in cervical squamous carcinoma tissue specificity high expression, may be in cervical squamous carcinoma of the occurrence, development and transfer plays an important role. 2. PDGF-D and VEGF expression and cervical squamous carcinoma of the differentiation degree and lymph node metastasis related, and age and clinical staging has nothing to do, prompt they may in cervical squamous carcinoma invasion and metastasis and prognosis of have an important monitoring significance. 3. PDGF-D and VEGF in cervical squamous carcinoma tissue of the positive correlation between expression, indicating both plays the role of the mutual promotion of PDGF- D and VEGF joint inspection, for clinical application provides reference.