ScholarLens Back to search
2004•Zhejiang Medical JournalRequires access

Serum soluble CD40L and its correlation with soluble intercellular adhesion molecule-1 in acute coronary syndrome

Qiu Yunxian

Open publisher page 0 citations

Abstract

Objective To investigate the correlation of serum soluble CD40L (sCD40L) with soluble intercellular adhesion molecule-1 (sICAM-1) in acute coronary syndrome (ACS). Methods Serum sCD40L and sICAM-1 levels were determined by ELISA in 48 patients with ACS, 38 patients with stable coronary heart disease (SCHD) and 30 healthy subjects. Results Serum sCD40L and sICAM-1 levels were significantly increased in ACS group compared with those in SCHD group and the controls(P0.01). A significant correlation was observed between serum sCD40L and sICAM-1 levels (r=0.436, P0.01). Conclusions Serum sCD40L is highly related to the pathogenesis of ACS, which might be related to up-regulating sICAM-1 expression and may represent one of the predictors of inflammation in ACS.

About this research paper

What this paper is about

Objective To investigate the correlation of serum soluble CD40L (sCD40L) with soluble intercellular adhesion molecule-1 (sICAM-1) in acute coronary syndrome (ACS). Methods Serum sCD40L and sICAM-1 levels were determined by ELISA in 48 patients with ACS, 38 patients with stable coronary heart disease (SCHD) and 30 healthy subjects. Results Serum sCD40L and sICAM-1 levels were significantly increased in ACS group compared with those in SCHD group and the controls(P0.01). A significant correlation was observed between serum sCD40L and sICAM-1 levels (r=0.436, P0.01). Conclusions Serum sCD40L is highly related to the pathogenesis of ACS, which might be related to up-regulating sICAM-1 expression and may represent one of the predictors of inflammation in ACS.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the correlation of serum soluble CD40L (sCD40L) with soluble intercellular adhesion molecule-1 (sICAM-1) in acute coronary syndrome (ACS). Methods Serum sCD40L and sICAM-1 levels were determined by ELISA in 48 patients with ACS, 38 patients with stable coronary heart disease (SCHD) and 30 healthy subjects. Results Serum sCD40L and sICAM-1 levels were significantly increased in ACS group compared with those in SCHD group and the controls(P0.01). A significant correlation was observed between serum sCD40L and sICAM-1 levels (r=0.436, P0.01). Conclusions Serum sCD40L is highly related to the pathogenesis of ACS, which might be related to up-regulating sICAM-1 expression and may represent one of the predictors of inflammation in ACS.

Key concepts: Medicine, Acute coronary syndrome, Pathogenesis, Intercellular Adhesion Molecule-1, Inflammation, Internal medicine, Intracellular, Coronary heart disease

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Serum soluble CD40L and its correlation with soluble intercellular adhesion molecule-1 in acute coronary syndrome — Research Paper | ScholarLens