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Study of VEGF and its receptor mRNA differential expression of normal pregnant and pre-eclampsia placenta

Hai Liu

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Abstract

Objective:To study the differential expression of the VEGF and VEGF-R in normal and preeclampsia placenta.Methods:Determine the level of the VEGF,VEGF-R1 and VEGF-R2 mRNA in the placenta of normal and preeclampsia pregnancy by Real Time RT-PCR.Results:All of the gene of VEGF,VEGF-R1 and VEGF-R2 at the level of transcription were compared in both normal and preeclampsia placenta,while the mRNA levels of the total VEGF and VEGFR-1 were increased 2.82-and 2.67-fold(P0.05),respectively,in PE vs normal placentas.The change of VEGF-R2 mRNA level was not significant.Conclusion:VEGF may play a role in the mechanism of preeclampsia through the VEGFR-1.

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What this paper is about

Objective:To study the differential expression of the VEGF and VEGF-R in normal and preeclampsia placenta.Methods:Determine the level of the VEGF,VEGF-R1 and VEGF-R2 mRNA in the placenta of normal and preeclampsia pregnancy by Real Time RT-PCR.Results:All of the gene of VEGF,VEGF-R1 and VEGF-R2 at the level of transcription were compared in both normal and preeclampsia placenta,while the mRNA levels of the total VEGF and VEGFR-1 were increased 2.82-and 2.67-fold(P0.05),respectively,in PE vs normal placentas.The change of VEGF-R2 mRNA level was not significant.Conclusion:VEGF may play a role in the mechanism of preeclampsia through the VEGFR-1.

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Available abstract

Objective:To study the differential expression of the VEGF and VEGF-R in normal and preeclampsia placenta.Methods:Determine the level of the VEGF,VEGF-R1 and VEGF-R2 mRNA in the placenta of normal and preeclampsia pregnancy by Real Time RT-PCR.Results:All of the gene of VEGF,VEGF-R1 and VEGF-R2 at the level of transcription were compared in both normal and preeclampsia placenta,while the mRNA levels of the total VEGF and VEGFR-1 were increased 2.82-and 2.67-fold(P0.05),respectively,in PE vs normal placentas.The change of VEGF-R2 mRNA level was not significant.Conclusion:VEGF may play a role in the mechanism of preeclampsia through the VEGFR-1.

Key concepts: VEGF receptors, Placenta, Medicine, Preeclampsia, Messenger RNA, Vascular endothelial growth factor, Andrology, Eclampsia

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