Effect of percutaneous intratumoral injection combined with hepatic artery perfused heated lipiodol on VX_2 tumor in rabbits

Objective To assess the suppression tumor effect of percutaneous intratumoral injection and hepatic artery perfused heated lipiodol(60 ℃) in treatment of VX2 tumor in rabbits.Methods VX2 tumor cells were vaccinated into left liver of 24 New Zealand white rabbits,and which were divided into 3 groups randomly: combined group received percutaneous intratumoral injection of combinning hepatic artery perfused 3ml heated lipiodol(60 ℃),normal group was perfused 3ml normal lipiodol(25 ℃) through hepatic artery,and control group was perfused chemotherapic agents by hepatic artery;the necrosis rate of the tumor was calculated,meanwhile,the survival period and AST level of blood serum were observed 10 days after the operation.Results Compared with control group(3.16±0.65) and normal group(1.52±0.36),the tumorous growth rate of combined group had significant differences(P0.05).And the survival period of combined group(48.3±3.0) was different obviously(P0.05) from control group(39.2±2.5) and normal group(39.2±2.5).The AST level of blood serum of the 3 groups did not have marked differences(P0.05) 10 days after the operation.Conclusion Effect of percutaneous intratumoral injection combined with hepatic artery perfused heated lipiodol(60 ℃) on VX2 tumor in rabbits is better than alone arterial embolism or chemotherapy,and could reduce the growth rate of tumor and prolong the survival time.