Preparation and Physicochemical Properties of Solid Lipid Nanoparticles Containing Praziquantel

OBJECTIVE:To prepare solid lipid nanoparticles containing praziquantel(PZQ-SLN)and investigate their physicochemical characteristics.METHODS:The PZQ-SLN was prepared with docosanoic acid glycerol ester and butyl acetate as matrix material by ultrasonic technique.Its morphology was examined by the transmission electron microscope.The particle size,entrapment efficience and Zeta potential were determined,and drug release profiles of PZQ-SLN were investigated.The stability of samples was studied as well.RESULTS:The morphological investigation showed that the nanoparticles had round and uniform shapes,the mean diameters were(100± 21)nm,the drug entrapment efficiency was(79.3± 0.69)%,and the average zeta potential was-66.3mV.The in vitro release was well in accordance with Weibull distribution.The particle size,entrapment efficiency and Zeta potential showed no obvious change after storing for 3 months at 4℃.CONCLUSION:The physicochemical characteristics of PZQ-SLN were satisfactory and the nanoparticles can deliver PZQ in a controlled manner.The PZQ-SLN was stable when stored at 4℃.