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Preparation and Physicochemical Property of Epirubicin Hydrochloride Solid Lipid Nanoparticles

Jianbin Pan

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Abstract

OBJECTIVE:To prepare epirubicin hydrochloride solid lipid nanoparticle(EPI-SLN) and investigate its physicochemical property. METHODS: EPI-SLN was prepared by ultrasonic dispersion technique with glyceryl behenate as matrix,and the appearance,particle size,ζ electric potential,and entrapment efficiency of the SLN were evaluated and its stability at 3 month storing at 4 ℃ was investigated. RESULTS: EPI-SLN assumed spherical shape with a particle diameter of (212.8±6.2) nm,ζ electric potential of (-24.7±0.3) mV and entrapment efficiency of 82 %. The EPI-SLN at 4 ℃ was stable after storing for 3 months,showing no marked change in mean diameter,ζ electric potential or entrapment efficiency. CONCLUSION: The prepared EPI-SLN is up to the standard.

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What this paper is about

OBJECTIVE:To prepare epirubicin hydrochloride solid lipid nanoparticle(EPI-SLN) and investigate its physicochemical property. METHODS: EPI-SLN was prepared by ultrasonic dispersion technique with glyceryl behenate as matrix,and the appearance,particle size,ζ electric potential,and entrapment efficiency of the SLN were evaluated and its stability at 3 month storing at 4 ℃ was investigated. RESULTS: EPI-SLN assumed spherical shape with a particle diameter of (212.8±6.2) nm,ζ electric potential of (-24.7±0.3) mV and entrapment efficiency of 82 %. The EPI-SLN at 4 ℃ was stable after storing for 3 months,showing no marked change in mean diameter,ζ electric potential or entrapment efficiency. CONCLUSION: The prepared EPI-SLN is up to the standard.

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Available abstract

OBJECTIVE:To prepare epirubicin hydrochloride solid lipid nanoparticle(EPI-SLN) and investigate its physicochemical property. METHODS: EPI-SLN was prepared by ultrasonic dispersion technique with glyceryl behenate as matrix,and the appearance,particle size,ζ electric potential,and entrapment efficiency of the SLN were evaluated and its stability at 3 month storing at 4 ℃ was investigated. RESULTS: EPI-SLN assumed spherical shape with a particle diameter of (212.8±6.2) nm,ζ electric potential of (-24.7±0.3) mV and entrapment efficiency of 82 %. The EPI-SLN at 4 ℃ was stable after storing for 3 months,showing no marked change in mean diameter,ζ electric potential or entrapment efficiency. CONCLUSION: The prepared EPI-SLN is up to the standard.

Key concepts: Solid lipid nanoparticle, Entrapment, Epirubicin, Particle size, Materials science, Chemistry, Zeta potential, Chromatography

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