Clinical Significance of Expression of COX-2 and MMP-9 in Cervical Carcinoma

【Objective】To investigate the clinical significance of the expressions of COX-2 and MMP-9 in cervical carcinoma.【Methods】Expression of COX-2 and MMP-9 in 90 paraffin embedded specimens of surgically treated cervical carcinoma patients were examined with immunohistochemistry method.【Results】The positive expression rates of COX-2 and MMP-9 were 40% and 36.7%,respectively,in cervical carcinoma of stageⅠ/Ⅱ,while it were 63.3% and 65%,respectively,in cervical carcinoma of stage Ⅲ/Ⅳ.There were significant differences in COX-2 and MMP-9 expression between the two groups(both P0.05).The positive expression rates of COX-2 and MMP-9 were 69% and 65.5%,respectively,in the group with lymph node metastasis,while they were 31.3% and 37.5%,respectively,in the group without lymph node metastasis.There were significant differences in COX-2 and MMP-9 expression between the two groups(both P0.05),and the expressions of MMP-9 was not significantly related to the pathological type and age.【Conclusion】The expression of COX-2 and MMP-9 could be used to estimate the metastasis potentiality and are helpful for the treatment.