2011•Xiandai shengwu yixue jinzhanRequires access
The Expression of PTEN in cervical lesions in Uygur females in Xinjiang
Zhang Hai-meng
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Abstract
Objective: To investigate the expression and significance of PTEN in normal cervix,and chronic cervicitis,cervical in-traepithelial neoplasiaⅠ(CINⅠ),CINⅡ/III and invasive squamous carcinoma of cervix from Uygur females in Xinjiang.Methods: 30 cases with normal cervix and chronic cervicitis,30 cases with CINⅠ,30 cases with CINⅡ/III and 30 cases of cervical squamous cell car-cinoma were tested for expression of PTEN by immunohistochemistry SP method.Results: The positive rates of PTEN protein in normal cervix and chronic cervicitis,cervical intraepithelial neoplasiaⅠ(CINⅠ),CINⅡ/III and invasive squamous carcinoma of cervix were83.3 %,73.3%,56.7%,23.3%,respectively.The PTEN expression in the SCC group was significantly lower than that in the other groups(P0.05).Conclusion: The expression of PTEN protein in cervical carcinoma is low,it was negative correlated with Uygur females in cervical lesions in Xinjiang,The detection of PTEN expression is helpful for understanding the biological behavior of cervical carcinogenesis.