A control study of Risperidone oral solution in treating chronic schizophrenia patients

Objective:To compare the efficacy and safety between Risperidone oral solution and Clozapine in the treatment of chronic schizophrenia patients.Methods:90 patients with chronic schizophrenia were randomly divided into study group(n=45) and control group(n=45),treated with Risperidone oral solution and Clozapine respectively for 8 weeks.The positive and negative syndomly scale(PANSS),Clinical Global Impression(CGI) was used to assess the therapeutic efficacy.The treatment emergent symptom scale(TESS) was used to assess side effect.Results: Risperidone oral solution was as effective as Clozapine for the treatment of chronic schizophrenia(P0.05).The marked improvement rate of the former was 70.5% and the later was 73.8%.The incidence rate of adverse effect was 50% in Risperidone oral solution group and that was 90.48% in Clozapine group.Significant differences were observed between them(P0.05).Conclusions: Risperidone oral solution is an effective and safe drug in the treatment of chronic schizophrenia.Its side effects were fewer.