Prevention Effects of Intra-incisiona Amikacin on Postoperative Wound Infections of Severe Appendicitis

OBJECTIVE To analyze the prevention effects of amikacin on postoperative wound infections in severe appendicitis by intra-incisional injection.METHODS A total of 156 severe appendicitis patients with suppuration,gangrenous,perforation and periappendiceal abscess were divided into two groups randomly.The patients in study group underwent the same appendectomy,and then were infiltrated and injected with 0.4g amikacin plus 5ml sodium chloride into muscular layer and stratum subcutaneum around incisions after suture of peritoneum;while the patients in control group were scrubbed with polividone iodine(Idophor) and soaked with metronidazole for 3-5 min on incisions.The incisions were sutured layer by layer using the same method.RESULTS There was no significant difference between two groups in age,sex,onset time and pathological type after operation(P0.05);the infection rate of incision in study group(1.28%)was lower than that in control group(10.26%) significantly (P0.05).CONCLUSIONS Postoperative wound infections in severe appendicitis could be prevented effectively by the injection of amikacin into incision.