2012•Unpublished venueRequires access
Distribution of plasma D-Dimer in cancer patients during chemotherapy
Jian Li
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Abstract
Objective To provide the evidence for excluding venous thromboembolism in patients with cancer during chemotherapy by investigating the change in their plasma D-Dimer concentration.Methods One hundred and one patients were divided into gastric cancer group,intestinal cancer group,and lung cancer group.Their plasma D-Dimer concentrations were measured by automatic immuno-turbidimetric assay and analyzed by ANOVA test in a general linear model.Results A significant difference was found in plasma D-Dimer concentration of patients with gastric,intestinal and lung cancer(F=8.634,P0.05).However,no significant difference was found in plasma D-Dimer concentration of patients with gastric and intestinal cancer or with a single cancer(F=1.358,F=0.565,P0.05).Cancer type and chemotherapy time had no combined action on plasma D-Dimer concentration(P0.05).Conclusion Chemotherapy does not influence the plasma D-Dimer concentration in cancer patients.The difference in plasma D-Dimer level among different types of cancer suggests that the critical plasma D-Dimer cutoff value should be established for the prognosis of such cancer patients.