Observations on Theraputic Effect of Oxymatrine on Liver Fibrosis Resulted from Chronic Hepatitis B

Objective: To observe the efficacy of Oxymatrine in treating of patients with fibrosis of hepatitis B.Methods: 43 patients with chronic hepatitis B were randomly divided into the treated group(22 cases) and the control group(21 cases),Patients in both groups received conventional drugs for 24 weeks,however,Patients in treated group also received Oxymatrine 600mg per oral daily for 24 weeks.HBeAg in ELISA and HBV-DNA with PCR were measured,Serum HA,LN,CIV and PCIII were measured in the above patients by radiommunoassay at 0,24 weeks treatment.Results: HBeAg of 8 in 22 cases(36.4%) of the treated group converted to negative,and HBV-DNA of 12 in 22 cases(54.5%) of the treated group converted to nagative.The serum levels of HA,LN,CIV and PCIII were decreased in the treated group,but there were no change during the period in the control group.There was significant difference between the two groups.Conclusion: Oxymatrine combined with conventional drugs is effective in treatment of fibrosis of chronic hepatitis B.