Change of coagulation indexes with women in labor and its clinical significance

Objective:To study the function of coagulation,anti-coagulation and fibrinolysis in later-pregnant women,and to study the clinical value of prothrombin time(PT),activated partial thrombopastin time(APTT),fibrinogen(Fib)and D-dimer in later-pregnant women.Methods:Routine coagulation tests PT,APTT,Fib,D-dimer were determined in plasma of 35 later-pregnant women and 40 normal controls.Results:No significant difference were found in the amounts of PT in two groups(P0.05),the amounts of APTT in later-pregnant women were lower than that in normal controls(P0.05).The amounts of Fib and D-dimer in later-pregnant women were significantly higher than that in normal controls(P0.001).Conclusions:The PT during pregnancy is not significant changed,PT can't indicate the activates coagulation state,however,all APTT,Fib and D-dimer can.D-dimer's increase in pregnant women also indicates the occurrence of secondary fibrinolysis.