Changes of D-dimer and blood coagulation index in normal pregnancy and three-day-postpartum

Objective:To study the clinical value of the changes of D-dimer(D-D),prothrombin time(PT),activated partial thrombopastin time(APTT),thrombin time(TT) and fibrinogen(FIB) in women during normal pregnancy and 3 days after delivery.Methods:The D-D,PT,APTT,FIB and TT of 80 healthy women(control group),240 normal pregnant women who were divided into 3 groups in accordance to the gestational weeks,and 80 three-day-postpartum women were determined using the hemagglutinin analyzer.Results:The PT in three-day-postpartum women was higher than the other groups(P0.05-P0.01),but PT in the prepregnancy,mid-pregnancy and late-pregnancy group were higher than the control group(P0.01);the FIB,APTT and D-D were statistically different in the mid-pregnancy group and the late-pregnancy group compared with those in other groups(P0.05-P0.01);the TT in the late-pregnancy group was significantly lower than the control group and the three-day-postpartum women(P0.05).Conclusions:Normal pregnant women are in a hypercoagulable state which is resumed about three days after delivery.Routine coagulation tests can be of great significance in preventing thrombosis in pregnant women.