Preparation of sustained-release pellets of sinomenine hydrochloride

Objective To prepare sinomenine hydrochloride sustained-release pellets,and investigate the drug release mechanism in vitro.Methods Sinomenine hydrochloride pellets were prepared by means of powder layering with the centrifugal granulation equipment.Sinomenine hydrochloride pellets were coated in the same equipment with Eudragit NE30D as coating material.The effects of the coating level and the amount of anti-adherent on the drug release rate from the sustained-release pellets were studied.Results The formulation of coating material was determined under single-factor investigation.The coated pellets had a remarkable sustained-release property,the drug release profile in vitro followed first order kinetics.Conclusion The prepared pellets met the release standard of 24 h sustained release formulation.