2013•Pharmaceutical and Clinical ResearchRequires access

Preparation of Sinomenine Hydrochloride Enteric-coated and Sustained-release Pellets

Liu Jian-ping

Abstract

Objective:To develop the sinomenine hydrochloride enteric-coated and sustained-release pellets.Methods:Sinomenine hydrochloride enteric-coated and sustained-release pellets were prepared with Eudragit NE30D,HPMC E5 and Eudragit L30D-55 coating by fluid-bed,then the dissolutions were detected at different coating levels.Results:The accumulative release of the prepared pellets in the artificial gastric juice after 2 hours was lower than 10% and dissolved slowly in artificial intestinal liquid in 8 hours.Conclusion:This preparation processing is simple and feasible with good reproducibility.And it may be used in industrial production.

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Key concepts: Pellets, Sinomenine, Enteric coated, Chromatography, Chemistry, Hydrochloride, Enteric coating, Coating