ScholarLens Back to search
2008•Chinese Journal of Hospital PharmacyRequires access

Preparation of sustained-release pellets of sinomenine hydrochloride

Lingyan Jian

Open publisher page 0 citations

Abstract

OBJECTIVE To prepare the sinomenine hydrochloride sustained-release pellets and study its in vitro drug release.METHODS Uncoated pellets were prepared in a centrifugal granulator by Powder-laying method.Eudragit dispersions were coated as a sustained-release layer in a fluid-bed equipment.The release mechanism of the drug from the pellets was studied.RESULTS The main factors affecting the release rate were the type and the amount of the coating material applied.Release of the drug from pellets was in accordance with Higuchi equation: Y=0.093 8+0.084 6t(r=0.996 5).CONCLUSION The method and the formulation are successful in providing slow and steady release of sinomenine hydrochloride from sustained-release pellets.

About this research paper

What this paper is about

OBJECTIVE To prepare the sinomenine hydrochloride sustained-release pellets and study its in vitro drug release.METHODS Uncoated pellets were prepared in a centrifugal granulator by Powder-laying method.Eudragit dispersions were coated as a sustained-release layer in a fluid-bed equipment.The release mechanism of the drug from the pellets was studied.RESULTS The main factors affecting the release rate were the type and the amount of the coating material applied.Release of the drug from pellets was in accordance with Higuchi equation: Y=0.093 8+0.084 6t(r=0.996 5).CONCLUSION The method and the formulation are successful in providing slow and steady release of sinomenine hydrochloride from sustained-release pellets.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE To prepare the sinomenine hydrochloride sustained-release pellets and study its in vitro drug release.METHODS Uncoated pellets were prepared in a centrifugal granulator by Powder-laying method.Eudragit dispersions were coated as a sustained-release layer in a fluid-bed equipment.The release mechanism of the drug from the pellets was studied.RESULTS The main factors affecting the release rate were the type and the amount of the coating material applied.Release of the drug from pellets was in accordance with Higuchi equation: Y=0.093 8+0.084 6t(r=0.996 5).CONCLUSION The method and the formulation are successful in providing slow and steady release of sinomenine hydrochloride from sustained-release pellets.

Key concepts: Pellets, Sinomenine, Chromatography, Chemistry, Pellet, Materials science, Coating, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Preparation of sustained-release pellets of sinomenine hydrochloride — Research Paper | ScholarLens