The expression and clinical role of p27 cyclin E protein in gastric carcinoma

Objective p27,cyclin E are prime cell cycle regulators and may be involved in tumorigenesis.p27,a cyclin-dependent kinase inhibitor,regulates progression from G 1 to S phase.Cyclin E is a late G 1 cyclin and its abnormalities have been reported in several cancers.The authors investigated their protein expression in normal gastric epithelium,tumor-sideward epithelium and carcinomatous tissues,and the correlation of their protein expression with the clinicopathologic features of gastric carcinoma.Methods The protein expressions of p27,cyclin E in 10 specimens of gastric noncarcinoma and 40 specimens of gastric carcinoma were studied by means of immunohistochemistry.Results There was no statistical significance between the expression′s differences of p27,cyclin E in the normal gastric epithelium and the tumor-sideward epithelium(P0.05).On statistical principle,their data were consolidated,compared with the carcinomatous tissues group.The positive expressions of p27 in the carcinomatous tissues were significantly lower than those in the normal gastric epithelium and the tumor-sideward epithelium (P0.01);by contraries,those of cyclin E were overexpressive,and significantly higher (P0.01).In the carcinomatous tissues,there was no relativity among the protein expressions of p27 and cyclin E (P0.05);but P=0.064 between p27 and cyclin E was close to 0.05,that might be correlative to the numbers of the specimens.At the same time,the p27 positive rate was 28% (11/40),which was frequently observed in high histopathological grade (P0.05),and prognosis bona (P0.05);the cyclin E positive rate was 75% (30/40),14 of which were medium-strongly positive,and often observed in deeply invasive (P0.05),and poor histopathological grade (P0.05).Conclusion Abnormal expression of p27,cyclin E may be related to the genesis and development of gastric carcinoma,and be used as a prognostic factor.