2008•Shiyong zhongliu zazhiRequires access

Expression of COX-2 and its relation to lymphangiogenesis in papillary thyroid carcinoma

Gui-Long Guo

Abstract

Objective To investigate the expression of cyclooxygenase-2(COX-2) and its relation to lymphangiogenesis in papillary thyroid carcinoma. Methods The tissue sections were collected from 60 cases of papillary thyroid carcinoma. The expression of COX-2 was detected by envision immunohistochemical staining; the lymph vessel density (LVD) was calculated by counting numbers of D2-40 positive lymph vessel. Results The positive COX-2 expression rate in papillary thyroid carcinoma was higher than that in normal thyroid tissue (χ2=25.34,P0.05). COX-2 expression rate in papillary thyroid carcinoma with lymph node metastasis was higher than that without lymph node metastasis (χ2=3.796,P0.05). The LVD in papillary thyroid carcinoma with lymph node metastasis was remarkably higher than that without lymph node metastasis (t=13.21,P0.01). COX-2 expression was positively correlated with LVD in papillary thyroid carcinoma (r=0.762,P0.01). Conclusion COX-2 may be involved in lynphangiogenesis and lymph node metastasis in papillary thyroid carcinoma.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Thyroid carcinoma, Lymphangiogenesis, Medicine, Immunohistochemistry, Pathology, Lymph node, Thyroid, Carcinoma