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2012•Journal of Jilin Medical CollegeRequires access

Effect of cisplatin on the proliferation of liver cancer Hepg2 cells

Wei Zhang

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Abstract

Objective To explore the effect of cisplatin on inhibiting proliferation of liver cancer HepG2 cells.Methods Cancer cell lines were cultured to exponential phase and divided into groups in which cisplatin of different concentration were added,while the untreated group was used as control.The inhibitory effect of cisplatin on cells was measured by MTT assay and the morphological changes of cells were also observed under optical microscope.Results MTT assay showed that cisplatin could inhibit the proliferation of HepG2 cells in dose-dependent manner.Conclusion Cisplatin could inhibit the proliferation of HepG2 cells.

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What this paper is about

Objective To explore the effect of cisplatin on inhibiting proliferation of liver cancer HepG2 cells.Methods Cancer cell lines were cultured to exponential phase and divided into groups in which cisplatin of different concentration were added,while the untreated group was used as control.The inhibitory effect of cisplatin on cells was measured by MTT assay and the morphological changes of cells were also observed under optical microscope.Results MTT assay showed that cisplatin could inhibit the proliferation of HepG2 cells in dose-dependent manner.Conclusion Cisplatin could inhibit the proliferation of HepG2 cells.

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Available abstract

Objective To explore the effect of cisplatin on inhibiting proliferation of liver cancer HepG2 cells.Methods Cancer cell lines were cultured to exponential phase and divided into groups in which cisplatin of different concentration were added,while the untreated group was used as control.The inhibitory effect of cisplatin on cells was measured by MTT assay and the morphological changes of cells were also observed under optical microscope.Results MTT assay showed that cisplatin could inhibit the proliferation of HepG2 cells in dose-dependent manner.Conclusion Cisplatin could inhibit the proliferation of HepG2 cells.

Key concepts: Cisplatin, MTT assay, Liver cancer, Cell growth, Chemistry, Cancer cell, Inhibitory postsynaptic potential, Cell

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