Correlation research between homocysteine,blood uric acid and the severity of coronary artery lesion

Objective To investigate the relations between the levels of serum homocysteine (HCY)and blood uric acid (UA) and the severity of coronary artery lesions of patients with coronary heart disease and predict whether the joint detection of HCY and UA can be an effective indicators for judging disease.Methods Among 88 cases of patients with coronary heart disease in department of cardiology,64 cases were selected as the observation group,while the other 24 cases were selected as the control group.The observation group included the acute myocardial infarction (AMI) group of 17 cases,25 cases of unstable angina pectoris (UAP) group,22 cases of stable angina pectoris (SAP) group.According to coronary angiography result of patients in AMI and UAP groups,the 2 groups were divided into single-vessel group of 15 cases,double vessels group of 14 cases,three vessels group of 13 cases.The serum levels of HCY、UA of all the patients were detected,and the data was statistically analyzed by using the statistical software SPSS 17.0.Results The serum HCY and UA level of the observation group were higher than that of the control group,and the difference was statistically significant (P0.05),and they increased in positive proportion to the severity of coronary artery lesion.It showed a good positive correlation between coronary heart disease and serum HCY and UA (r=0.841,P0.01) .Conclusion The concentration of HCY and UA can be regarded as an important risk factor for coronary heart disease.And the serum level of HCY can reflect the severity of coronary heart disease and coronary artery lesion.